Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.
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چکیده
منابع مشابه
Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.
Recombinant adenoviruses (Ads) efficiently transfer foreign genes into hepatocytes in vivo, but the duration of transgene expression is limited by the host immune response which precludes gene expression upon readministration of the virus. To test if this immune response can be abrogated by oral tolerization, we instilled protein extracts of a recombinant adenovirus type-5 via gastroduodenostom...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119238